We find that trans-acting RBPs extensively regulate U2AF2 binding in vivo, including enhanced recruitment to 3′ splice sites and clearance of introns. We measure U2AF2 affinities at hundreds of binding sites and compare in vitro and in vivo binding landscapes by mathematical modeling. We establish “in vitro iCLIP” experiments, in which recombinant RBPs are incubated with long transcripts, to study how U2AF2 recognizes RNA sequences and how this is modulated by trans-acting RBPs. The RNA-binding protein (RBP) U2AF2 is central to splicing decisions, as it recognizes 3′ splice sites and recruits the spliceosome. YouTube sets this cookie via embedded youtube-videos and registers anonymous statistical data.Alternative splicing generates distinct mRNA isoforms and is crucial for proteome diversity in eukaryotes. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously. Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Provided by Google Tag Manager to experiment advertisement efficiency of websites using their services. The pattern element in the name contains the unique identity number of the account or website it relates to. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors.Ī variation of the _gat cookie set by Google Analytics and Google Tag Manager to allow website owners to track visitor behaviour and measure site performance. The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc. It does not store any personal data.Īnalytical cookies are used to understand how visitors interact with the website. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It works only in coordination with the primary cookie. Records the default button state of the corresponding category & the status of CCPA. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. The cookies is used to store the user consent for the cookies in the category "Necessary". The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Advertisement" category. This cookie is set by the Google recaptcha service to identify bots to protect the website against malicious spam attacks.
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